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Smart nanofibers as biosensors for medical and non-medical application

Effective, reliable, cheap and user-friendly biosensors attract a growing

attention of medical personnel as well as environmental specialists

worldwide. Nanofiber-based sensors seem to belong among top candidates

for a highly sensitive detection system. Clearly, among main advantages

of nanofibers belongs a tremendously high ratio between their surface and

volume. Large surface makes from nanofibers a naturally effective

material for non-specific adhesion. In addition, a polymer composition of

nanofibers enables their both specific and non-specific surface

modification. Namely, a specific surface modification creates from

functionalized nanofibers a highly potent tool for an easy and highly

specific detection of extremely low concentrations in gasses as well as

in fluids. Thus, functionalized nanofibers could effectively serve as

sensitive sensors of traces in urine, blood, sweat, exudates or breath.

In addition, nanofibers functionalized with a selected antibody could be a

subject for a subsequent fractionalization. Fractionalization keeps all

positive nanofiber properties, but in particles several microns large.

Consequently, these particles with kept internal nanofiber substructure

are small enough for their distribution into gels, foams or fluids. This

technology is opening a path towards  an injectable system for

laparoscopic applications. An application in oncology and alergology is

going to be shown as an example for application smart nanofibers.

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