Smart nanofibers as biosensors for medical and non-medical application
Effective, reliable, cheap and user-friendly biosensors attract a growing
attention of medical personnel as well as environmental specialists
worldwide. Nanofiber-based sensors seem to belong among top candidates
for a highly sensitive detection system. Clearly, among main advantages
of nanofibers belongs a tremendously high ratio between their surface and
volume. Large surface makes from nanofibers a naturally effective
material for non-specific adhesion. In addition, a polymer composition of
nanofibers enables their both specific and non-specific surface
modification. Namely, a specific surface modification creates from
functionalized nanofibers a highly potent tool for an easy and highly
specific detection of extremely low concentrations in gasses as well as
in fluids. Thus, functionalized nanofibers could effectively serve as
sensitive sensors of traces in urine, blood, sweat, exudates or breath.
In addition, nanofibers functionalized with a selected antibody could be a
subject for a subsequent fractionalization. Fractionalization keeps all
positive nanofiber properties, but in particles several microns large.
Consequently, these particles with kept internal nanofiber substructure
are small enough for their distribution into gels, foams or fluids. This
technology is opening a path towards an injectable system for
laparoscopic applications. An application in oncology and alergology is
going to be shown as an example for application smart nanofibers.